Endocrine Abstracts

Introduction: Cushing’s Syndrome secondary to inhaled or topic corticosteroids is very rare, although there are reports of a link to cytochrome inhibitors. Ritonavir, a protease inhibitor used for treatment in human immunodeficiency virus (HIV) infection, is a potent inhibitor of cytochrome P450 3A4.The case: A 41 years old man - with personal history of asthma, HIV infection diagnosed in 2002 and hepatitis C infection since 1999 – was sent to ...

Idiopathic congenital hypogonadotropic hypogonadism (CHH) is a rare reproductive disorder that is primarily caused by a gonadotrophin-realising hormone (GnRH) deficiency. When CHH is associated with hyposmia or anosmia is designated by Kallmann Syndrome (KS). This syndrome is a genetic disorder with significant genetic heterogeneity that may present as a sporadic or familial case, following autosomal dominant, autosomal recessive, or X – linked recessive modes of inherita...

Hypophysitis are a heterogeneous group of inflammatory lesions affecting the hypophysis. Have been described hypophysitis secondary to administration of immunomodulatory drugs such as interferon and anti-cytotoxic T lymphocyte antigen-4 antibodies (CTLA-4). Ipilimumab is an anti-CTLA-4 human monoclonal antibody that blocks the union between CTLA-4 and B7 receptor on antigen-presenting cells causing an antitumoral effect and increasing the production of autoantibodies. Hypophys...

A 50-year-old woman with no history of interest who was admitted in hospital for progressive headache 2 weeks of evolution refractory to treatment that was accompanied by emetic syndrome and paresthesias in face and arms. A CT scan of the skull (urgency) was performed which was normal. Neurology improves with analgesia and steroids, presenting mild drowsiness and mild hyponatremia (121 mEq/l). A cerebral MRI was performed, showing a right subacute hemorrhagic adenoma of 1 cm t...

Objective: To study the GLP-1 pattern of secretion after an oral glucose tolerance test (OGTT) in women in postpartum reassessment of previous gestational diabetes (GDM). To evaluate clinical and laboratory parameters that can influence GLP-1 secretion.Patients and methods: Forty-eight women with a history of GDM were assessed one year after childbirth determining clinical and analytical characteristics and OGTT with 75 g. We measured glucose, insulin an...

Introduction: Both insulin resistance and oxidative stress are implicated in the pathophysiology of various diseases such as type 2 diabetes mellitus, atherosclerosis or liver disease. Furthermore, the uncoupling protein-1 (UCP1) is involved in induced thermogenesis, related to the pathogenesis of obesity and diabetes. The aim of this study was to assess the impact of aerobic exercise on the inflammatory profile in patients with chronic hepatitis C.Metho...

Introduction: There is a reduction of the incretin effect in patients with type 2 diabetes secondary to altered secretion of incretin hormones and/or failed of its action.Objective: To study the GLP-1 secretion pattern after an oral glucose tolerance test (OGTT) in postpartum reassessment of women with previous GDM.Materials and methods: Prospective epidemiological study of 48 women with a history of GDM. We evaluated age, history ...

Although, diabetes type I patients in Portugal have complete and free access to HbA1c management (via multiple daily injections) only a few percentage has been provided an insulin pump – priority is given to children and women in fertile age trying to get pregnant. By the end of 2014, 1.150 insulin pumps had already been provided by the National Program of Insulin Pumps, but at least 3.000 patients with indication for insulin pump use were in waiting list. HbA1c pre-pump ...

Introduction: The incidence of glucose metabolism alterations during the follow-up of surgically treated insulinomas is largely unknown. Our aim was to evaluate the incidence, and the clinical characteristics, of diabetes and prediabetes in this population.Methods: We retrospectively analyzed the cases diagnosed as insulinomas in a Central Hospital in Portugal in the period between January 1980 and December 2015.Results: We identif...

Background: Germline heterozygous mutations in the MEN1 gene located on chromosome 11q13, predisposes to the development of tumors in multiple endocrine tissues. The MEN1 gene encodes a protein of 610 amino acid residues, known as menin which is involved in genome stabilization as well as in several steps of cellular division, conferring tumor suppression activity in MEN1-associated target tissues. The three main endocrine tissues affected by tumors in MEN1 are parathyroid (95...